The Apache Spark + Alluxio stack is getting quite popular particularly for the unification of data access across S3 and HDFS. In addition, compute and storage are increasingly being separated causing larger latencies for queries. Alluxio is leveraged as compute-side virtual storage to improve performance. But to get the best performance, like any technology stack, you need to follow the best practices. This article provides the top 10 tips for performance tuning for real-world workloads when running Spark on Alluxio with data locality giving the most bang for the buck.