Alluxio, formerly Tachyon, is a memory speed virtual distributed storage system and leverages memory for storing data and accelerating access to data in different storage systems. Many organizations and deployments use Alluxio with Apache Spark, and some of them scale out to over PB’s of data. Alluxio can enable Spark to be even more effective, in both on-premise deployments and public cloud deployments. Alluxio bridges Spark applications with various storage systems and further accelerates data intensive applications. In this talk, we briefly introduce Alluxio, and present different ways how Alluxio can help Spark jobs. We discuss best practices of using Alluxio with Spark, including RDDs and DataFrames, as well as on-premise deployments and public cloud deployments.